![]() ![]() Several hypotheses emerged from the literature, but little is known about the specific pathophysiology of COVID-19-associated ARDS. Most of the patients admitted to ICU for coronavirus disease 2019 (COVID‐19) present severe respiratory failure fulfilling acute respiratory distress syndrome (ARDS) criteria according to the Berlin definition. C RS become similar for patients remaining on mechanical ventilation during the first week of evolution, but oxygenation becomes lower in COVID-19 patients. Conclusionsįor a similar initial oxygenation, COVID-19 ARDS initially differs from classical ARDS by a higher C RS, dissociated from oxygenation. ![]() Day-28 mortality did not differ between COVID-19 and non-COVID-19 patients (25.9% and 23.7%, respectively, p = 0.666). After adjustment on PaO 2/FiO 2, PEEP and humidification device, C RS and VR were found not different between COVID-19 and non-COVID-19 patients at day 7. VR was higher at days 1, 3 and 7 in the COVID-19 patients ventilated using heat and moisture exchangers compared to heated humidifiers. ![]() VR was lower at day 1 in COVID-19 than in non-COVID-19 patients but increased from day 1 to 7 only in COVID-19 patients. Oxygenation became lower in COVID-19 than in non-COVID-19 patients at days 3 and 7, while C RS became similar. At day 1, C RS was correlated with oxygenation only in non-COVID-19 patients 61.6% and 68.2% of COVID-19 and non-COVID-19 pulmonary ARDS were still ventilated at day 7 ( p = 0.241). ![]() COVID-19 patients had a higher body mass index, higher C RS at day 1 (median, 35 vs 32 ml cmH 2O −1, p = 0.037). The two groups were similar on initial oxygenation. A propensity-matching was based on age, severity score, oxygenation, positive end-expiratory pressure (PEEP) and pulmonary cause of ARDS and allowed to include 112 COVID-19 and 198 non-COVID pulmonary ARDS. This study aimed to compare initial values and longitudinal changes in respiratory system compliance ( C RS), oxygenation parameters and ventilatory ratio (VR) in patients with COVID-19 and non-COVID-19 pulmonary ARDS matched on oxygenation.ġ35 patients with COVID-19 ARDS from two centers were included in a physiological study 767 non-COVID-19 ARDS from a clinical trial were used for the purpose of at least 1:2 matching. Differences in physiology of ARDS have been described between COVID-19 and non-COVID-19 patients. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |